2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Related Products

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Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.

Nucleoside Antimetabolite/Analog Related Products (2419):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-Z15868
    5-Hydroxycytidine
    		99.77%
    5-Hydroxycytidine is the RNA modified nucleoside that can be found in the 23S rRNA of bacteria E. coli. 5-Hydroxycytidine modifies at the C2501 site, exhibits a higher modification level in stationary cells. 5-Hydroxycytidine exhibits a higher modification level in radiation resistant Radius than in E. coli.
    5-Hydroxycytidine
  • HY-154481
    3’-O-Me-C(Bz)-2’-phosphoramidite
    3’-O-Me-C(Bz)-2’-phosphoramidite is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    3’-O-Me-C(Bz)-2’-phosphoramidite
  • HY-43059
    5'-O-DMT-2'-O-iBu-N-Bz-Guanosine
    		98.12%
    5'-O-DMT-2'-O-iBu-N-Bz-Guanosine could be used for silyl protection of ribonucleosides.
    5'-O-DMT-2'-O-iBu-N-Bz-Guanosine
  • HY-131800A
    3'-NH2-ATP tetrasodium, 100 mM Solution
    		98.70%
    3'-NH2-ATP tetrasodium is an ATP substitute created by inserting an amino acid at the C3 position of ATP. 3'-NH2-ATP tetrasodium catalyzes RNA synthesis in the presence of RNA polymerase.
    3'-NH2-ATP tetrasodium, 100 mM Solution
  • HY-77651
    Nucleoside-Analog-1
    Nucleoside-Analog-1 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Nucleoside-Analog-1
  • HY-180690A
    Imidazole-4-pyruvic acid TFA
    Imidazole-4-pyruvic acid is derived from histidine catalyzed by histidine transaminase. Imidazole-4-pyruvic acid can be used as a precursor for selective His-labeling in E.coli overexpressed proteins.
    Imidazole-4-pyruvic acid TFA
  • HY-177164
    3'-NH2-TTP
    3'-NH2-TTP is a nucleotide analogue with an amino group modified at the 3' end of TTP.
    3'-NH2-TTP
  • HY-W114328
    DMT-OMe-rC(Ac)
    DMT-OMe-rC(Ac) (N-Acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methylcytidine) is a nucleotide derivative that can be used to synthesize oligoribonucleotides.
    DMT-OMe-rC(Ac)
  • HY-152710
    5-Methoxycarbonylmethyl-2-thiouridine
    		99.52%
    5-Methoxycarbonylmethyl-2-thiouridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    5-Methoxycarbonylmethyl-2-thiouridine
  • HY-W048518
    7-Deaza-2'-dG
    7-Deaza-2'-dG (7-Deaza-2'-deoxyguanosine) is a monomeric raw material that can be used for nucleic acid synthesis.
    7-Deaza-2'-dG
  • HY-152684
    2′-O-2-Propyn-1-ylguanosine
    		98.46%
    2′-O-2-Propyn-1-ylguanosine is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7). 2′-O-2-Propyn-1-ylguanosine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    2′-O-2-Propyn-1-ylguanosine
  • HY-W113081
    4′-Thiouridine
    		98.68%
    4′-Thiouridine (1-(4-Thio-beta-D-ribofuranosyl)uracil) is a thio analog of thymidine. 4′-Thiouridine can be used to synthesize 4'-thionucleosides with antiviral and anticancer activities. 4′-Thiouridine can be used for RNA-sequencing.
    4′-Thiouridine
  • HY-W726201
    5'-DMT-5-F-2'-dU Phosphoramidite
    		98.0%
    2'-Deoxy-5'-O-DMT-5-fluorouridine 3'-CE phosphoramidite is a nucleoside phosphoramidite analogue employed in oligonucleotide synthesis. This compound contributes to crafting therapeutic oligonucleotides for drugs targeting cancers.
    5'-DMT-5-F-2'-dU Phosphoramidite
  • HY-134178
    5-F-UTP
    5-F-UTP (5-Fluorouridine-5'-triphosphate) is a monomeric raw material that can be used for nucleic acid synthesis.
    5-F-UTP
  • HY-182338
    2’-Thiouridine
    2'-Thiouridine is a key modified nucleoside at the wobble position of tRNA anticodons. 2'-Thiouridine mainly exists in tRNAs for glutamic acid, glutamine, lysine, etc., and participates in precise decoding regulation.
    2’-Thiouridine
  • HY-134291
    8-Chloro-2'-deoxyadenosine
    8-Chloro-2'-deoxyadenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).
    8-Chloro-2'-deoxyadenosine
  • HY-B1449S5
    Uridine-d2
    		99.0%
    Uridine-d2 is the deuterium labeled Uridine.
    Uridine-d<sub>2</sub>
  • HY-W008048S
    2',3'-O-Isopropylideneadenosine-13C5
    2',3'-O-Isopropylideneadenosine-13C5 is the 13C-labeled 2',3'-O-Isopropylideneadenosine (HY-W008048). 2',3'-O-Isopropylideneadenosine is a nucleoside compound and also a Golgi-targeting moiety. 2',3'-O-Isopropylideneadenosine constitutes a furanose ribose group that undergoes cyclization at the O (2') and O (3') atoms. As a component of the fluorescent probe TPE-Ade, 2',3'-O-Isopropylideneadenosine enables specific Golgi localization for fluorescence imaging. 2',3'-O-Isopropylideneadenosine participates in the synthesis of aggregation-induced emission (AIE) fluorescent probes.
    2',3'-O-Isopropylideneadenosine-<sup>13</sup>C<sub>5</sub>
  • HY-154779R
    5′-Deoxy-5-fluoro-N-[(2-methylbutoxy)carbonyl]cytidine (Standard)
    5′-Deoxy-5-fluoro-N-[(2-methylbutoxy)carbonyl]cytidine (Standard) is the analytical standard of 5′-Deoxy-5-fluoro-N-[(2-methylbutoxy)carbonyl]cytidine. This product is intended for research and analytical applications. 5′-Deoxy-5-fluoro-N-[(2-methylbutoxy)carbonyl]cytidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    5′-Deoxy-5-fluoro-N-[(2-methylbutoxy)carbonyl]cytidine (Standard)
  • HY-136650
    Fludarabine triphosphate
    Fludarabine triphosphate (F-ara-ATP), the active metabolite of Fludarabine (HY-B0069), is a potent, noncompetitive and specific inhibitor of DNA primase, with an IC50 of 2.3 μM and a Ki of 6.1 μM. Fludarabine triphosphate inhibits DNA synthesis by blocking DNA primase and primer RNA formation. Fludarabine triphosphate inhibits ribonucleotide reductase and DNA polymerase and ultimately leads to cellular apoptosis.
    Fludarabine triphosphate